Реакция #50375

Уравнение реакции

hydrochloric acid

sodium hydride

methyl isoferulate

glycidol

→

cinnamic acid

Растворители

DMSO

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added gradually
2. 2
   ТемператураHeating
3. 3
   ТемператураThe system was cooled
4. 4
   Другоеwas removed

Методика

3 g of methyl isoferulate was dissolved in 600 ml of DMSO, and 370 mg of sodium hydride was added. The system was heated to 90° C. under N2 gas flow and 7 g of glycidol was added gradually. Heating and agitation was carried out for 0.5 hours. The system was cooled, neutralized by adding hydrochloric acid, solvent was removed and adduct of cinnamic acid and glycerin was obtained.

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