Реакция #5028

Уравнение реакции

7-bromo-2,3,4,5-tetrahydro-1H-1-benzazepine-9-carboxylic acid

potassium carbonate

benzyl bromide

→

compound

Выход 99.7%

7-Bromo-2,3,4,5-tetrahydro-1H-1-benzazepine-9-carboxylic acid benzyl ester

Выход 99.7%

Растворители

DMF

Условия реакции

Обработка

1. 1
   ФильтрацияAfter the insoluble matter was filtered off
2. 2
   Концентрированиеthe filtrate was concentrated
3. 3
   workup.ADDITIONa mixed liquid of ethyl acetate-benzene (1:1, 400 ml) was added to the residue
4. 4
   Промывкаthe mixture was washed with water
5. 5
   Сушкаdried over anhydrous sodium sulfate
6. 6
   workup.DISTILLATIONto distilling off the solvent

Методика

To 7-bromo-2,3,4,5-tetrahydro-1H-1-benzazepine-9-carboxylic acid (8.53 g) dissolved in DMF (80 ml), were added potassium carbonate (13.8 g) and benzyl bromide (4.5 ml) and the mixture was stirred for 2 hours at room temperature. After the insoluble matter was filtered off and the filtrate was concentrated, a mixed liquid of ethyl acetate-benzene (1:1, 400 ml) was added to the residue, and the mixture was washed with water, dried over anhydrous sodium sulfate and then subjected to distilling off the solvent to give the intended compound 11.35 g (99.7%) as brown oily matter.

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