Реакция #5023

Уравнение реакции

ethanol

N-acetyl-5-bromo-7-nitroindoline

hydrochloric acid

→

compound

Выход 32.2%

N-acetyl-7-amino-5-bromoindoline

Выход 32.2%

Растворители

water

Условия реакции

Обработка

1. 1
   Температураto refluxing for 5 hours with vigorous stirring
2. 2
   ФильтрацияThe reaction mixture was filtered by suction while hot
3. 3
   Другоеto remove insoluble matter
4. 4
   Концентрированиеthe filtrate thereof was concentrated
5. 5
   Температураcooled

Методика

To a mixed solution of ethanol (400 ml) and water (100 ml), were added N-acetyl-5-bromo-7-nitroindoline (133.1 g), iron powder (10 mesh; 75 g) and concentrated hydrochloric acid (5 ml), and the mixture was subjected to refluxing for 5 hours with vigorous stirring. The reaction mixture was filtered by suction while hot to remove insoluble matter, and then the filtrate thereof was concentrated and cooled on standing to give the intended compound 38.3 g (32.2%) as a brown needle crystal. M.P.: 154°-155° C.

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