Реакция #50229

Уравнение реакции

water

Aluminium trichloride

5-(2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

bromoacetyl bromide

→

title compound

Выход 78.4%

5-(5-Bromoacetyl-2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one

Выход 78.4%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   ДругоеThe organic phase was separated
2. 2
   Экстракцияthe aqueous phase further extracted with dichloromethane (2×100 ml)
3. 3
   Сушкаdried (Na2SO4)
4. 4
   Другоеevaporated under vacuum
5. 5
   Другоеto give an off-white solid, trituration of which from ether

Методика

Aluminium trichloride (12.8 g, 0.096 mol) was added portionwise over 1 hour to a stirred solution of 5-(2-ethoxyphenyl)-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one (10.0 g, 0.032 mol) and bromoacetyl bromide (5.6 ml, 0.064 mol) in dichloromethane (150 ml) at 0° C. After 18 hours at room temperature, the reaction mixture was poured into ice and water (400 g) and the resulting mixture stirred vigorously. The organic phase was separated and the aqueous phase further extracted with dichloromethane (2×100 ml). The organic solutions were combined, dried (Na2SO4) and evaporated under vacuum to give an off-white solid, trituration of which from ether gave the title compound as a white solid (10.87 g, 78%), m.p. 159°-160° C. Found: C,52.54; H,4.88; N,12.78. C19H21BrN4O3 requires C,52.67; H,4,88; N,12.93%.

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