Реакция #502275

Уравнение реакции

3-morpholinopropan-1-ol

DIEA

Mesylchloride

→

3-morpholinopropyl methanesulfonate

Растворители

dichloromethane

dichloromethane

Условия реакции

Методика

A flask was charged with 3-morpholinopropan-1-ol (1.0 g, 6.9 mmol), DIEA (2.4 mL, 14 mmol) and dichloromethane (100 mL). Mesylchloride (0.64 mL, 8.3 mmol) was added in a drop wise fashion to the dichloromethane mixture and the reaction mixture was stirred at room temperature for 15 hours. Concentration of the reaction mixture gave rise to a quantitative yield of 3-morpholinopropyl methanesulfonate, which was used in the next step without any further purification.

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