Реакция #502149

ord-6f1c8c7822014db5a8d99688561bc42a

Уравнение реакции

CSc1nc(Cc2cccc(Cl)c2)[nH]c(=O)c1C#N
2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile
COCCN
2-methoxyethylamine
COCCNc1nc(Cc2cccc(Cl)c2)[nH]c(=O)c1C#N
title compound
COCCNc1nc(Cc2cccc(Cl)c2)[nH]c(=O)c1C#N
2-(3-Chlorobenzyl)-4-[(2-methoxyethyl)amino]-6-oxo-1,6-dihydropyrimidine-5-carbonitrile

Условия реакции

Подробные условия
See reaction.notes.procedure_details.

Методика

In analogy to the preparation of Example 1, 100 mg (0.34 mmol) of 2-(3-chlorobenzyl)-4-(methylsulphanyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile are reacted with 257 mg (3.43 mmol) of 2-methoxyethylamine to give 61 mg (56% of theory) of the title compound.

Источник

DOI: 10.6084/m9.figshare.5104873.v1Патент: US08088769B2uspto-grants-2012_01