Реакция #502105

Уравнение реакции

2-bromoisonicotinic acid

N,O-dimethylhydroxylamine hydrochloride

1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide

pyridine

→

compound

Выход 82.4%

2-Bromo-N-methoxy-N-methylisonicotinamide

Выход 82.4%

Растворители

tetrahydrofuran

Условия реакции

Обработка

1. 1
   КонцентрированиеThe mixture is concentrated
2. 2
   ПромывкаThe organic phase is washed with 50 ml of a 1N solution of sodium hydroxide and 50 ml of a saturated solution of sodium chloride
3. 3
   Сушкаdried over magnesium sulphate
4. 4
   Концентрированиеconcentrated under reduced pressure

Методика

In a round-bottomed flask, 2.0 g of 2-bromoisonicotinic acid, 1.1 g of N,O-dimethylhydroxylamine hydrochloride, 3.8 g of 1-(3-dimethylaminopropyl)-3-ethyl-carbodiimide and 3.2 ml of pyridine are placed in 50 ml of tetrahydrofuran. The mixture is stirred at ambient temperature for 40 h. The mixture is concentrated, and the residue is taken up in 50 ml of ethyl acetate and 50 ml of water. The organic phase is washed with 50 ml of a 1N solution of sodium hydroxide and 50 ml of a saturated solution of sodium chloride, dried over magnesium sulphate and then concentrated under reduced pressure. 2.0 g of compound are obtained.

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