Реакция #502102

Уравнение реакции

[4-[(2-quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol

hydrochloric acid

→

compound

[4-[(2-Quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol hydrochloride

Растворители

dichloromethane

isopropanol

methanol

Условия реакции

Обработка

1. 1
   workup.ADDITIONare added to the filtrate
2. 2
   КонцентрированиеThe reaction mixture is then concentrated under reduced pressure
3. 3
   ФильтрацияThe precipitate is recovered by filtration
4. 4
   Другоеoven-dried under reduced pressure

Методика

100 mg of [4-[(2-quinolin-3-yl)imidazo[1,2-a]pyridin-6-yl]thien-2-yl]methanol are suspended in dichloromethane and methanol. The solution is passed through a frit and 5.6 ml of a 0.1N solution of hydrochloric acid in isopropanol are added to the filtrate. The reaction mixture is then concentrated under reduced pressure and the residue is then taken up in diethyl ether. The precipitate is recovered by filtration and oven-dried under reduced pressure. 106 mg of compound are obtained.

Источник