Реакция #502099

Уравнение реакции

2-(4-chlorophenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine

hydrochloric acid

diethyl ether

→

compound

Выход 199.0%

[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-6-yl]boronic acid hydrochloride

Выход 199.0%

Растворители

acetone

water

Условия реакции

Обработка

1. 1
   workup.STIRRINGthe mixture is stirred at ambient temperature for 24 h
2. 2
   КонцентрированиеThe reaction mixture is then concentrated under reduced pressure
3. 3
   ДругоеThe solid obtained
4. 4
   Фильтрацияrecovered by filtration
5. 5
   Другоеdried in an oven under reduced pressure at 60° C

Методика

3.60 g of 2-(4-chlorophenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine are dissolved in 112 ml of acetone and 56 ml of water; 101 ml of 1N hydrochloric acid are added thereto, dropwise and with stirring, and the mixture is stirred at ambient temperature for 24 h. The reaction mixture is then concentrated under reduced pressure. The solid obtained is titurated with diethyl ether and recovered by filtration, and then dried in an oven under reduced pressure at 60° C. 3.12 g of compound are obtained.

Источник