Реакция #502098

Уравнение реакции

5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamine

2-bromo-1-(4-chlorophenyl)ethanone

sodium hydrogen carbonate

→

compound

Выход 93.2%

2-(4-Chlorophenyl)-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyridine

Выход 93.2%

Растворители

n-propanol

Условия реакции

Обработка

1. 1
   workup.WAITThe reaction mixture is left
2. 2
   Температураto cool
3. 3
   Концентрированиеconcentrated under reduced pressure
4. 4
   Другоеthe organic phase is then separated
5. 5
   Сушкаdried over magnesium sulphate
6. 6
   Другоеthe solvent is then evaporated off under reduced pressure

Методика

2.5 g of 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-ylamine and 2.65 g of 2-bromo-1-(4-chlorophenyl)ethanone in 76 ml of n-propanol are placed in a round-bottomed flask. 1.33 g of sodium hydrogen carbonate are added thereto. The mixture is heated at 80° C. for 16 h. The reaction mixture is left to cool and concentrated under reduced pressure. The residue is taken up between water and ethyl acetate, the organic phase is then separated by settling out and dried over magnesium sulphate, and the solvent is then evaporated off under reduced pressure. 3.75 g of compound are obtained.

Источник