Реакция #501645

Уравнение реакции

Water

sodium hydroxide

6-chloro-N-(1H-5-tetrazolyl)pyrazine-2-carboxamide

o-toluidine

→

6-[(2-Methylphenyl)amino]-N-(1H-5-tetrazolyl)-pyrazine-2-carboxamide

Растворители

dimethylsulfoxide

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   Температураthe mixture was heated for 24 hours at 100°-110 ° C
3. 3
   Промывкаthe aqueous alkaline solution was washed with chloroform
4. 4
   ФильтрацияAqueous layer was filtered
5. 5
   ФильтрацияThe precipitate was collected by filtration
6. 6
   Другоеrecrystalized from a mixture of dimethylformamide and ethanol affording 0.19 g of the desired compound as dark yellow crystals, m.p. 277°-282° C. (decomp.)

Методика

To a suspension of 1.13 g of 6-chloro-N-(1H-5-tetrazolyl)pyrazine-2-carboxamide in 5 ml of dimethylsulfoxide, 5.35 ml of o-toluidine was added, and the mixture was heated for 24 hours at 100°-110 ° C. Water and 10%-sodium hydroxide aqueous solution were added to the reaction mixture, and the aqueous alkaline solution was washed with chloroform. Aqueous layer was filtered and the filtrate was adjusted with 10%-hydrochloric acid to pH 3. The precipitate was collected by filtration, and recrystalized from a mixture of dimethylformamide and ethanol affording 0.19 g of the desired compound as dark yellow crystals, m.p. 277°-282° C. (decomp.).

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