Реакция #49948

Уравнение реакции

Methyl dichlorophosphine

N-benzoyl-N'-t-butyl hydrazine

ether

o-chloroaniline

→

N'-t-butyl-N'-[methyl-(2-chlorophenylamino)phosphinyl]-N-benzoylhydrazine

Растворители

triethylamine

methylene chloride

Условия реакции

Обработка

1. 1
   Другоеproducing a mild exotherm
2. 2
   ДругоеThe reaction was quenched 2 minutes later with water (20 ml) and ether (20 ml)
3. 3
   Другоеseparated
4. 4
   Промывкаthe organic washed with 0.1N HCl
5. 5
   Сушкаdried over MgSO4
6. 6
   Фильтрацияfiltered

Методика

Methyl dichlorophosphine (1.3 g) in ether (10 ml) and triethylamine (2 ml) were added to a stirred solution of N-benzoyl-N'-t-butyl hydrazine (1.0 g) in methylene chloride (3 ml). After stirring 5 minutes at room temperature, o-chloroaniline was added neat producing a mild exotherm. The reaction was quenched 2 minutes later with water (20 ml) and ether (20 ml), separated and the organic washed with 0.1N HCl, dried over MgSO4, filtered and rotavapped to a colorless oil weighing 0.5 g.

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