Реакция #49920

Уравнение реакции

oxalyl chloride

beta-trifluoromethylcrotonic acid

N'-t-butyl-N-benzoylhydrazine

beta-trifluoromethylcrotonyl chloride

→

N'-t-butyl-N-benzoyl-N'-(beta-trifluoromethylcrotonyl)hydrazine

Растворители

toluene

toluene

Условия реакции

Обработка

1. 1
   Другоеthe reaction mixture was partitioned between saturated aqueous sodium bicarbonate (20 ml) and ether (20 ml)
2. 2
   ДругоеThe ether layer was evaporated under reduced pressure to about 10 ml
3. 3
   Другоеthe excess hydrazine was removed by filtration
4. 4
   ДругоеThe filtrate was evaporated

Методика

N'-t-butyl-N-benzoylhydrazine (1.0 g,) in 2 ml toluene was added dropwise to a solution of beta-trifluoromethylcrotonyl chloride (prepared by addition of oxalyl chloride (1.3 g) to a solution of 1.5 g beta-trifluoromethylcrotonic acid in 5 ml toluene at 23° C.). After 30 minutes at 23° C., the reaction mixture was partitioned between saturated aqueous sodium bicarbonate (20 ml) and ether (20 ml). The ether layer was evaporated under reduced pressure to about 10 ml and the excess hydrazine was removed by filtration. The filtrate was evaporated to give N'-t-butyl-N-benzoyl-N'-(beta-trifluoromethylcrotonyl)hydrazine as a colorless oil.

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