Реакция #49908

Уравнение реакции

N'-t-butyl-N,N'-dibenzoylhydrazine

Methoxymethyl chloride

→

N-methoxymethyl-N'-t-butyl-N,N'-dibenzoylhydrazine

Растворители

toluene

Условия реакции

Обработка

1. 1
   ДругоеThe layers were separated
2. 2
   Промывкаthe toluene layer was washed several times with water (until the water washes
3. 3
   СушкаThe toluene solution was dried over anhydrous magnesium sulfate
4. 4
   Другоеthe toluene removed under vacuum

Методика

N'-t-butyl-N,N'-dibenzoylhydrazine (2 g, 0.007M) was stirred at room temperature in a two phase system of toluene-50% sodium hydroxide with 100 mg of phase transfer catalyst (tetra-n-butylammonium hydrogen sulfate). Methoxymethyl chloride (1.2 g, 0.015M) was added dropwise and the mixture was stirred 3 hours. The layers were separated and the toluene layer was washed several times with water (until the water washes were neutral). The toluene solution was dried over anhydrous magnesium sulfate and the toluene removed under vacuum to afford N-methoxymethyl-N'-t-butyl-N,N'-dibenzoylhydrazine as a thick oil.

Источник