Реакция #49803

Уравнение реакции

water

Benzyl alcohol

triethylamine

{o-[5-(2,4-dichlorophenoxy)-2-nitrophenoxy]phenoxy}acetyl chloride

→

title product

Выход 77.8%

Benzyl {o-[5-(2,4-dichlorophenoxy)-2-nitrophenoxy]phenoxy}acetate

Выход 77.8%

Растворители

tetrahydrofuran

—

hexanes

methylene chloride

Условия реакции

Обработка

1. 1
   Экстракцияextracted with ether
2. 2
   ПромывкаThe combined organic extracts are washed sequentially with one molar hydrochloric acid, water and brine
3. 3
   Сушкаdried over anhydrous magnesium sulfate
4. 4
   Концентрированиеconcentrated in vacuo
5. 5
   Другоеto obtain an oil

Методика

Benzyl alcohol (0.8 mL, 7.73 mmol) and triethylamine (1 mL, 7.17 mmol) are added to a mixture of {o-[5-(2,4-dichlorophenoxy)-2-nitrophenoxy]phenoxy}acetyl chloride (1.12 g, 2.38 mmol) in tetrahydrofuran. The reaction mixture is stirred for twenty minutes, poured into water and extracted with ether. The combined organic extracts are washed sequentially with one molar hydrochloric acid, water and brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to obtain an oil. Column chromatography of the oil using silica gel and a hexanes in methylene chloride solution gives the title product as a yellow oil (1.0 g) which is identified by NMR spectral analyses.

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