Реакция #49788

Уравнение реакции

2-chloro-α,α,α,6-tetrafluoro-p-tolyl 3,4-dinitrophenyl ether

4methoxyphenol

potassium carbonate

water

→

title product

Выход 25.2%

4-[(2-Chloro-α,α,α,6-tetrafluoro-p-tolyl)oxy]-2-(p-methoxyphenoxy)-1-nitrobenzene

Выход 25.2%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Температураis refluxed for 18 hours
2. 2
   Экстракцияextracted with ethyl acetate
3. 3
   ЭкстракцияThe organic extract
4. 4
   Промывкаis washed with brine
5. 5
   Сушкаdried over anhydrous sodium sulfate
6. 6
   Концентрированиеconcentrated in vacuo
7. 7
   Другоеto obtain an amber oil

Методика

A mixture of 2-chloro-α,α,α,6-tetrafluoro-p-tolyl 3,4-dinitrophenyl ether (10.0 g, 0.026 mol), 4methoxyphenol (6.45 g, 0.052 mol) and potassium carbonate (7.26 g, 0.052 mol) in acetonitrile is refluxed for 18 hours, cooled to room temperature, poured into water and extracted with ethyl acetate. The organic extract is washed with brine, dried over anhydrous sodium sulfate and concentrated in vacuo to obtain an amber oil. Column chromatography of the oil using silica gel and a (1:4) ether/hexanes solution gives the title product as a yellow oil (3.0 g) which is identified by 1HNMR and 13CNMR spectral analyses.

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