Реакция #4969

Уравнение реакции

4-butoxyphenylacetylene

3,4,5-trifluorobromobenzene

triethylamine

→

3,4,5-trifluoro-4'-butoxytolan

Растворители

methyl tert.-butyl ether

Условия реакции

Обработка

1. 1
   Фильтрацияfiltered with suction
2. 2
   Другоеthe solution is evaporated
3. 3
   ДругоеPurification
4. 4
   Другоеby chromatography and/or crystallization

Методика

0.4 mmol of bis(triphenylphosphine)palladium(II) chloride and 0.2 mmol of CuI are added at room temperature to a mixture of 0.02 m of 4-butoxyphenylacetylene, 0.02 m of 3,4,5-trifluorobromobenzene and 50 ml of triethylamine. The reaction mixture is stirred at room temperature for 2 hours, diluted with methyl tert.-butyl ether and filtered with suction, and the solution is evaporated. Purification by chromatography and/or crystallization gives 3,4,5-trifluoro-4'-butoxytolan.

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