Реакция #4968

Уравнение реакции

4-ethoxyphenylacetylene

3,4-difluoroiodobenzene

triethylamine

→

3,4-difluoro-4'-ethoxytolan

Растворители

methyl tert.-butyl ether

Условия реакции

Обработка

1. 1
   Фильтрацияfiltered with suction
2. 2
   Другоеthe solution is evaporated
3. 3
   ДругоеPurification
4. 4
   Другоеby chromatography and/or crystallization

Методика

0.4 mmol of bis(triphenylphosphine)palladium(II) chloride and 0.2 mmol of CuI are added at room temperature to a mixture of 0.02 m of 4-ethoxyphenylacetylene, 0.02 m of 3,4-difluoroiodobenzene and 50 ml of triethylamine. The reaction mixture is stirred at room temperature for 2 hours, diluted with 100 ml of methyl tert.-butyl ether and filtered with suction, and the solution is evaporated. Purification by chromatography and/or crystallization gives 3,4-difluoro-4'-ethoxytolan, K 67 I, Δε=11.18.

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