Реакция #49618

Уравнение реакции

cumylamine

triethylamine

2,5-dichloropyridine-3-carbonylchloride

→

2,5-dichloro-N-(1-methyl-1-phenylethyl)nicotinamide

Выход 94.0%

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Другоеfollowed by purification by slurry

Методика

In a similar manner to Step 1 of Example 16, 2,5-dichloropyridine-3-carbonylchloride (669 mg, 3.19 mmol) was dissolved in dichloromethane (13 mL), and the solution was treated with cumylamine (0.505 mL, 3.51 mmol), triethylamine (0.667 mL, 4.79 mmol) and DMAP (39.0 mg, 0.319 mmol), followed by purification by slurry using diisopropylether/hexane to obtain 2,5-dichloro-N-(1-methyl-1-phenylethyl)nicotinamide (926 mg, yield 94%).

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