Реакция #49600

Уравнение реакции

4-chloro-5-hydroxy-7-iodoisoindolinone

potassium carbonate

(4-bromo-2-methyl-2-butoxy)triethylsilane

→

4-chloro-5-[3-methyl-3-(triethylsiloxy)butoxy]-7-iodoisoindolinone

Выход 35.0%

Растворители

DMF

Условия реакции

Обработка

1. 1
   Другоеfollowed by purification by flash column chromatography (chloroform/methanol=99/1)

Методика

In a similar manner to Step 1 of Example 429, 4-chloro-5-hydroxy-7-iodoisoindolinone (70.8 mg, 0.229 mmol) was dissolved in DMF (2.1 mL), and the solution was treated with potassium carbonate (94.8 mg, 0.686 mmol), tetrabutylammonium iodide (8.5 mg, 0.023 mmol) and (4-bromo-2-methyl-2-butoxy)triethylsilane (193 mg, 0.686 mmol), followed by purification by flash column chromatography (chloroform/methanol=99/1) to obtain 4-chloro-5-[3-methyl-3-(triethylsiloxy)butoxy]-7-iodoisoindolinone (40.7 mg, yield 35%).

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