Реакция #495241

Уравнение реакции

Metformin hydrochloride

metformin hydrochloride

magnesium stearate

→

Metformin

Растворители

water

Условия реакции

Обработка

1. 1
   Другоеdried in the same device
2. 2
   ДругоеDried granulate
3. 3
   ДругоеObtained granulate
4. 4
   Другоеis obtained

Методика

Metformin hydrochloride is screened through 1 mm sieve. Screened metformin hydrochloride and hydroxypropylmethylcellulose are granulated in fluid bed granulator with demineralized water and dried in the same device. Dried granulate is screened through 1 mm sieve. Obtained granulate and microcrystalline cellulose are homogenously blended in a bin blender. Pre-sieved magnesium stearate is added to the obtained blend and blended in a bin blender so that the final blend is obtained.

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