Реакция #49475

Уравнение реакции

7-amino-4-(4-tert-butyldimethylsilyloxy-3-methoxyphenyl)isoindolinone

potassium iodide

iodine

tert-butyl nitrate

→

7-iodo-4-(4-tert-butyldimethylsilyloxy-3-methoxyphenyl)isoindolinone

Выход 62.0%

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Другоеfollowed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=5/1)

Методика

In a similar manner to Step 4 of Example 140, 7-amino-4-(4-tert-butyldimethylsilyloxy-3-methoxyphenyl)isoindolinone (43.0 mg, 0.110 mmol) was dissolved in acetonitrile (6 mL), and the solution was treated with potassium iodide (29.2 mg, 0.176 mmol), copper iodide (33.5 mg, 0.896 mmol), iodine (44.7 mg, 0.896 mmol) and tert-butyl nitrate (0.059 mL, 0.50 mmol), followed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=5/1) to obtain 7-iodo-4-(4-tert-butyldimethylsilyloxy-3-methoxyphenyl)isoindolinone (33.8 mg, yield 62%).

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