Реакция #493779

Уравнение реакции

methylhydrazine

2,6-difluoroacetophenone

1,2-diethyl ethanedioate

sodium tert-butoxide

→

title compound

Выход 12.5%

ethyl 5-(2,6-difluorophenyl)-1-methyl-1H-pyrazole-3-carboxylate

Выход 12.5%

Растворители

ethanol

ethanol

Условия реакции

Обработка

1. 1
   workup.WAITwas continued for 1 h
2. 2
   ДругоеThe reaction mixture was partitioned between hydrochloric acid (1 N) and diethyl ether
3. 3
   ДругоеThe organic phase was separated
4. 4
   Сушкаdried over magnesium sulfate
5. 5
   Фильтрацияfiltered
6. 6
   Концентрированиеconcentrated under reduced pressure to half its original volume
7. 7
   workup.STIRRINGstirring
8. 8
   workup.WAITwas continued overnight
9. 9
   КонцентрированиеThe reaction mixture was concentrated under reduced pressure
10. 10
    Другоеthe resulting material was purified by silica gel chromatography (5 to 20% gradient of ethyl acetate in methylene chloride as eluant)

Методика

To a mixture of 2,6-difluoroacetophenone (4.7 g, 0.03 mol) and 1,2-diethyl ethanedioate (4.8 g, 0.033 mol) in ethanol (33 mL) was added sodium tert-butoxide (3.17 g, 0.033 mol). After 1 h, more ethanol (30 mL) was added to the reaction mixture and stirring was continued for 1 h. The reaction mixture was partitioned between hydrochloric acid (1 N) and diethyl ether. The organic phase was separated, dried over magnesium sulfate, filtered, and concentrated under reduced pressure to half its original volume. To the resulting mixture was added methylhydrazine (1.52 g, 0.033 mol) and stirring was continued overnight. The reaction mixture was concentrated under reduced pressure and the resulting material was purified by silica gel chromatography (5 to 20% gradient of ethyl acetate in methylene chloride as eluant) to provide the title compound as a solid (1.0 g).

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