Реакция #49355

Уравнение реакции

4-methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

trifluoroacetic acid

triethylsilane

→

4-methoxy-7-iodoisoindolinone

Выход 78.0%

Растворители

nitromethane

Условия реакции

Обработка

1. 1
   ФильтрацияThe obtained solid was collected by filtration
2. 2
   Промывкаwashed with ethyl acetate
3. 3
   ДругоеThe obtained solid was dried under reduced pressure

Методика

In a similar manner to Step 4 of Example 16, 4-methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (2.50 g, 5.91 mmol) was dissolved in nitromethane (100 mL), and the solution was treated with trifluoroacetic acid (4.50 mL, 59.1 mmol) and triethylsilane (1.90 mL, 11.8 mmol). The obtained solid was collected by filtration and washed with ethyl acetate. The obtained solid was dried under reduced pressure to obtain 4-methoxy-7-iodoisoindolinone (1.32 g, yield 78%).

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