Реакция #49288

Уравнение реакции

4-chloro-7-(1-(tert-butoxycarbonyl)indol-2-yl)isoindolinone

hydrogen chloride methanol

→

Compound 16

Выход 83.0%

4-Chloro-7-(1H-indol-2-yl)isoindolinone

Выход 83.0%

Растворители

methanol

Условия реакции

Обработка

1. 1
   Другоеfollowed by purification by preparative thin-layer chromatography (chloroform/acetone=12/1)

Методика

In a similar manner to Step 3 of Example 1, 4-chloro-7-(1-(tert-butoxycarbonyl)indol-2-yl)isoindolinone (39.3 mg, 0.103 mmol) was dissolved in methanol (3.9 mL), and the solution was treated with 10% hydrogen chloride-methanol solution (3.9 mL), followed by purification by preparative thin-layer chromatography (chloroform/acetone=12/1) to obtain Compound 16 (24 mg, yield 83%).

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