Реакция #489703

Уравнение реакции

benzyl bromide

7-chloro-6-fluoro-2H-isoquinolin-1-one

7-Chloro-6-fluoro-2H-isoquinolin-1-one

→

title compound

Выход 54.2%

1-Benzyloxy-7-chloro-6-fluoro-isoquinoline

Выход 54.2%

Растворители

toluene

Условия реакции

Обработка

1. 1
   ТемператураAfter cooling down to room temperature
2. 2
   Фильтрацияthe reaction mixture was filtered
3. 3
   Другоеthe filtrate was evaporated
4. 4
   workup.DISSOLUTIONThe residue was dissolved in dichloromethane
5. 5
   Промывкаwashed with water
6. 6
   Сушкаdried with magnesium sulfate
7. 7
   Другоеevaporated
8. 8
   ДругоеFinal purification by preparative HPLC

Методика

14.74 g (74.6 mmol) of 7-chloro-6-fluoro-2H-isoquinolin-1-one (7) were dissolved in 150 ml of toluene. After addition of 30.86 g (111.9 mmol) of silver carbonate and 15.31 g (89.5 mmol) of benzyl bromide, the mixture was stirred at 80° C. for 3 h. After cooling down to room temperature, the reaction mixture was filtered and the filtrate was evaporated. The residue was dissolved in dichloromethane and washed with water, dried with magnesium sulfate and evaporated. Final purification by preparative HPLC gave 11.63 g of the title compound. Rt=2.51 min (Method B). Detected mass: 288.1/290.1 (M+H+).

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