Реакция #489700

Уравнение реакции

7-chloro-6-fluoro-isoquinoline 2-oxide

7-Chloro-6-fluoro-isoquinoline 2-oxide

POCl3

→

title compound

1,7-Dichloro-6-fluoro-isoquinoline

Условия реакции

Обработка

1. 1
   Температураat reflux for 4 h
2. 2
   workup.ADDITIONit was poured on ice
3. 3
   ЭкстракцияThe aqueous solution was extracted three times with dichloromethane
4. 4
   СушкаThe combined organic layers were dried with magnesium sulfate
5. 5
   Другоеevaporated

Методика

2.6 g (12.0 mmol) of 7-chloro-6-fluoro-isoquinoline 2-oxide (5) were heated in 40 ml of POCl3 at reflux for 4 h. After the mixture had cooled down to room temperature, it was poured on ice. The aqueous solution was extracted three times with dichloromethane. The combined organic layers were dried with magnesium sulfate and evaporated to yield 2.91 g of the title compound, which was used without further purification. Rt=2.34 min (Method A). Detected mass: 216.0/218.0 (M+H+).

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