Реакция #48920

Уравнение реакции

4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one

Selectfluor

→

4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one

Растворители

acetonitrile

Условия реакции

Обработка

1. 1
   Концентрированиеconcentrated
2. 2
   Другоеpurified by silica gel chromatography (7:3→1:4; hexanes:ethyl acetate)

Методика

A mixture of 4-amino-8-(cyclopentyloxy)-7-methoxy-2H-chromen-2-one (100 mg, 0.36 mmol, Example 3, Step 1), Selectfluor (160 mg, 0.45 mmol), and acetonitrile (1.5 mL) were stirred vigorously for 18 h, concentrated, and then purified by silica gel chromatography (7:3→1:4; hexanes:ethyl acetate) to give 4-amino-8-(cyclopentyloxy)-3-fluoro-7-methoxy-2H-chromen-2-one: MS (ESI): 294.0.

Источник