Реакция #4884

Уравнение реакции

8-Hydroxy-2-methyl-7-quinolinecarboxylic acid

boron trifluoride

sodium bicarbonate

→

title compound

8-Hydroxy-2-methyl-7-quinolinecarboxylic acid methyl ester

Условия реакции

Обработка

1. 1
   Другоеto give finally a basic solution
2. 2
   ЭкстракцияThe solution is extracted with chloroform
3. 3
   ЭкстракцияThe chloroform extract
4. 4
   Сушкаis dried over anhydrous sodium sulfate
5. 5
   Концентрированиеconcentrated
6. 6
   Другоеthe residue is crystallized from a suitable solvent such as isooctane

Методика

8-Hydroxy-2-methyl-7-quinolinecarboxylic acid (as reported by Meek, W. H. et al., in J. Chem. Eng. Data 1969, 14(3), 388-91) is reacted with methanolic boron trifluoride solution for several hours. The resulting mixture is added to an aqueous solution of sodium bicarbonate to give finally a basic solution. The solution is extracted with chloroform. The chloroform extract is dried over anhydrous sodium sulfate and concentrated and the residue is crystallized from a suitable solvent such as isooctane to give the title compound.

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