Реакция #4872

Уравнение реакции

ethyl (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetate

sodium hydroxide

→

(Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid

Выход 75.1%

Растворители

methanol

Условия реакции

Обработка

1. 1
   Температураthe mixture is refluxed for 30 minutes
2. 2
   Температураunder heating
3. 3
   ТемператураAfter cooling
4. 4
   Другоеcrystalline precipitates
5. 5
   Фильтрацияare collected by filtration
6. 6
   Промывкаwashed with methanol
7. 7
   ДругоеCrystalline precipitates
8. 8
   Фильтрацияare collected by filtration
9. 9
   Другоеdried

Методика

16.0 g of ethyl (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetate are added to a mixture of 160 ml of methanol and 30 ml of an aqueous 2N sodium hydroxide solution, and the mixture is refluxed for 30 minutes under heating. After cooling, crystalline precipitates are collected by filtration and washed with methanol. The crystals are suspended in 30 ml of water. Then, the suspension is adjusted to pH 3 with 2N hydrochloric acid. Crystalline precipitates are collected by filtration and dried. 11.4 g of (Z)-2-(2-tritylaminothiazol-4-yl)-2-[(2-pyrrolidon-3-yl)oxyimino]acetic acid are obtained.

Источник