Реакция #48631

Уравнение реакции

1-bromobutane

5-[2-(S)-acetylamino-1-(S)-hydroxy-3-(3-hydroxyphenyl)-propyl]-2-(R)-(2,2-dimethylpropoxy)-3-(S)-methylmorpholine-4-carboxylic acid tert-butyl ester

cesium carbonate

→

title compound

Выход 102.5%

5-(R)-[2-(S)-Acetylamino-3-(3-butoxyphenyl)-1-(S)-hydroxypropyl]-2-(R)-(2,2-dimethylpropoxy)-3-(S)-methylmorpholine-4-carboxylic acid tert-butyl ester

Выход 102.5%

Растворители

N,N-dimethylformamide

ethyl acetate

Условия реакции

Обработка

1. 1
   Промывкаwash with water
2. 2
   Сушкаdry (magnesium sulfate)
3. 3
   Фильтрацияfilter
4. 4
   Концентрированиеconcentrate
5. 5
   Другоеpurify
6. 6
   Промывка(silica gel chromatography, eluting with 20:80 to 85:15 ethyl acetate:dichloromethane)

Методика

Add 1-bromobutane (6 μL, 55.6 μmol) to a solution of 5-[2-(S)-acetylamino-1-(S)-hydroxy-3-(3-hydroxyphenyl)-propyl]-2-(R)-(2,2-dimethylpropoxy)-3-(S)-methylmorpholine-4-carboxylic acid tert-butyl ester (25 mg, 50.5 μmol) and cesium carbonate (33 mg, 1.01 mmol) in N,N-dimethylformamide (250 μL). Heat to 60° C. for 3 hours. Dilute with ethyl acetate, wash with water, dry (magnesium sulfate), filter, concentrate and purify (silica gel chromatography, eluting with 20:80 to 85:15 ethyl acetate:dichloromethane) to give the title compound (28.5 mg, 80%).

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