Реакция #485198

Уравнение реакции

2-Methoxybenzoyl chloride

2-Methoxybenzoyl Chloride

2-hydroxyacetophenone

hydrochloric acid

→

compound

Выход 89.6%

2-[(2-Methoxybenzoyl)oxy]-acetophenone

Выход 89.6%

Растворители

pyridine

Условия реакции

Обработка

1. 1
   ФильтрацияThe solid was filtered off
2. 2
   Промывкаwashed with water
3. 3
   Другоеdried
4. 4
   ДругоеThe crude product was crystallized from methanol

Методика

2-Methoxybenzoyl chloride (about 51 g) from Example 1a was added dropwise to a mixture of 2-hydroxyacetophenone (27.2 g, 24.1 ml, 0.20 mol) and pyridine (40 ml). The reaction mixture was warmed to about 60° C. exothermically. After stirring for 15 minutes, the reaction mixture was poured onto a mixture of ice (800 g) and 36% hydrochloric acid (120 ml). The solid was filtered off, washed with water, and dried. The crude product was crystallized from methanol to yield 48.4 g (89.6%) of the compound (m.p.: 78-79° C.).

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