Реакция #48431

Уравнение реакции

di-tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(1,3-thiazol-2-ylmethyl)azepan-3-yl]imidodicarbonate

trifluoroacetic acid

→

title compound

Выход 0.1%

(3R,6S)-3-Amino-6-(2,3-difluorophenyl)-1-(1,3-thiazol-2-ylmethyl)azepan-2-one

Выход 0.1%

Растворители

sodium bicarbonate

DCM

Условия реакции

Обработка

1. 1
   Другоеthe layers separated
2. 2
   Экстракцияthe aqueous phase extracted with DCM (2×)
3. 3
   Сушкаdried over magnesium sulfate
4. 4
   Концентрированиеconcentrated

Методика

A solution of di-tert-butyl [(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(1,3-thiazol-2-ylmethyl)azepan-3-yl]imidodicarbonate (0.481 g, 0.895 mmol) in DCM (10 mL) was treated with trifluoroacetic acid (3 mL). After 1 h the reaction was diluted with saturated aqueous sodium bicarbonate, the layers separated, and the aqueous phase extracted with DCM (2×). The organic washes were combined, dried over magnesium sulfate, and concentrated to afford the title compound (0.30 mg). MS 338.2 (M+1).

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