Реакция #48425

Уравнение реакции

Trifluoroacetic acid

tert-butyl (3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(pyridin-2-ylmethyl)azepan-3-ylcarbamate

→

(3R,6S)-3-Amino-6-(2,3-difluorophenyl)-1-(pyridin-2-ylmethyl)azepan-2-on

Растворители

dichloromethane

Условия реакции

Обработка

1. 1
   Концентрированиеthe solution was concentrated
2. 2
   workup.ADDITIONSaturated aqueous sodium bicarbonate solution was added
3. 3
   Экстракцияthe mixture was extracted with dichloromethane (3×)
4. 4
   ПромывкаThe combined organic extracts were washed with saturated brine
5. 5
   Сушкаdried over magnesium sulfate
6. 6
   Фильтрацияfiltered
7. 7
   Концентрированиеconcentrated

Методика

Trifluoroacetic acid (3 mL) was added to a solution of tert-butyl (3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(pyridin-2-ylmethyl)azepan-3-ylcarbamate (202 mg, 0.468 mmol) in dichloromethane (4 mL). After 18 h, the solution was concentrated. Saturated aqueous sodium bicarbonate solution was added and the mixture was extracted with dichloromethane (3×). The combined organic extracts were washed with saturated brine, dried over magnesium sulfate, filtered and concentrated. MS 332.2 (M+1).

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