Реакция #48331

Уравнение реакции

3-(Benzyloxy)cyclobutanone Methylsulfinyl(methylthio)methane

n-Butyllithium

water

1-((1,3-dibromopropan-2-yloxy)methyl)benzene

→

3-(benzyloxy)cyclobutanone

Растворители

THF

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   ТемператураThe mixture was cooled down to −78° C.
3. 3
   workup.STIRRINGThe reaction was stirred over night
4. 4
   Температураto warm up to RT
5. 5
   Экстракцияextracted with EtOAc
6. 6
   ДругоеThe combined organic extracts were evaporated
7. 7
   workup.DISSOLUTIONdissolved in ether (50 ml)
8. 8
   workup.ADDITIONtreated with conc. HCl (10 ml) for 30 min
9. 9
   Температураat reflux
10. 10
    Экстракцияextracted with EtOAc
11. 11
    СушкаThe combined organic extracts were dried over MgSO4
12. 12
    Другоеevaporated

Методика

3-(Benzyloxy)cyclobutanone Methylsulfinyl(methylthio)methane (13 ml, 125 mmol) was dissolved in 250 ml THF and cooled to −20° C. n-Butyllithium (50 ml, 125 mmol) was added and the mixture was stirred for 3 h at −20° C. The mixture was cooled down to −78° C. and a solution of 1-((1,3-dibromopropan-2-yloxy)methyl)benzene (16.000 g, 52 mmol) was added. The reaction was stirred over night and allowed to warm up to RT. It was stirred for an additional 6h at RT, hydrolyzed with water and extracted with EtOAc. The combined organic extracts were evaporated, dissolved in ether (50 ml) and treated with conc. HCl (10 ml) for 30 min at reflux. The mixture was neutralized with NaOH (10M) and extracted with EtOAc. The combined organic extracts were dried over MgSO4 and evaporated. Glass col. Chrom. (10-50% EtOAc in Hex) gave 3-(benzyloxy)cyclobutanone as a yellow oil.

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