Реакция #482628

Уравнение реакции

5-iodo-1,2,3-trimethoxybenzene

aluminum chloride

→

title compound

2,6-Dimethoxy-4-iodophenol

Растворители

1,2-dichloroethane

Условия реакции

Обработка

1. 1
   Другоеevaporated
2. 2
   workup.DISSOLUTIONThe residue was dissolved in 1 M aqueous sodium hydroxide solution
3. 3
   Промывкаwashed with ether
4. 4
   Экстракцияextracted with chloroform
5. 5
   ПромывкаThe organic layer was washed with brine
6. 6
   Сушкаdried over anhydrous magnesium sulfate
7. 7
   Другоеevaporated

Методика

To a solution of 5-iodo-1,2,3-trimethoxybenzene (3.2 g) in 1,2-dichloroethane (40 mL) was added aluminum chloride (1.6 g). The mixture was stirred at 60° C. for 4 hours and evaporated. The residue was dissolved in 1 M aqueous sodium hydroxide solution and washed with ether. The aqueous layer was then acidified and extracted with chloroform. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and evaporated to give the title compound as white crystalline powder.

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