Реакция #482009

Уравнение реакции

water

sodium percarbonate

5-difluoromethoxy-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]thio]-1H-benzimidazol

acetic acid

→

pantoprazol

Растворители

methanol

Условия реакции

Обработка

1. 1
   workup.ADDITIONwere added
2. 2
   workup.ADDITIONwere added
3. 3
   ЭкстракцияThe mixture is extracted with 5 ml of dichloromethane
4. 4
   Другоеthe organic phase separated
5. 5
   Промывкаwashed with 10 ml of water
6. 6
   ДругоеThe solvent was evaporated at a reduced pressure

Методика

310 mg of 5-difluoromethoxy-2-[[(3,4-dimethoxy-2-pyridinyl)methyl]thio]-1H-benzimidazol were dissolved in 1.5 ml of methanol and 12 mg of ammonium molybdate added. The solution was cooled to 51C and 0.11 g of sodium percarbonate were added, then kept stirred at the same temperature for 4 h. After the reaction ended 3 ml of water were added, then heating to 20° C. and adjusting the mixture of the pH to 7.5 with acetic acid. The mixture is extracted with 5 ml of dichloromethane and the organic phase separated, then washed with 10 ml of water. The solvent was evaporated at a reduced pressure. 274 mg of pantoprazol were obtained (yield: 88%).

Источник