Реакция #482008

Уравнение реакции

acetic acid

sodium percarbonate

2-[[[3-methyl-4-(3-methoxypropoxy)-2-pyridinyl]methyl]thio]-1H-benzimidazol

water

→

rabeprazol

Растворители

methanol

Условия реакции

Обработка

1. 1
   workup.ADDITIONwere added
2. 2
   Температураheating to 20° C.
3. 3
   ЭкстракцияThe mixture is extracted with 50 ml of dichloromethane
4. 4
   Другоеthe organic phase was separated
5. 5
   Промывкаwhich was then washed with 100 ml of water
6. 6
   ДругоеThe solvent was evaporated at a reduced pressure

Методика

2.3 g of 2-[[[3-methyl-4-(3-methoxypropoxy)-2-pyridinyl]methyl]thio]-1H-benzimidazol were dissolved in 11.5 ml of methanol and 90 mg of ammonium molybdate were added. The solution was cooled to 5° C. and 0.87 g of sodium percarbonate were added, then kept stirred at this temperature for 6 h. After the reaction finished 22 ml of water were added, then heating to 20° C. and adjusting the pH of the mixture to 7.5 with acetic acid. The mixture is extracted with 50 ml of dichloromethane and the organic phase was separated, which was then washed with 100 ml of water. The solvent was evaporated at a reduced pressure. 2.0 g of rabeprazol were obtained (yield: 81%).

Источник