Реакция #482007

Уравнение реакции

acetic acid

sodium percarbonate

2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]thio]-1H-benzimidazol

water

→

lansoprazol

Растворители

methanol

Условия реакции

Обработка

1. 1
   workup.ADDITIONwere added
2. 2
   workup.STIRRINGThis was kept stirred for 1 hour
3. 3
   Другоеthe solid obtained
4. 4
   Фильтрацияwas filtered
5. 5
   Промывкаsubsequently washed with water
6. 6
   Другоеdried in a vacuum oven at 40° C

Методика

10 g of 2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]thio]-1H-benzimidazol were dissolved in 50 ml of methanol and 0.3 g of ammonium molybdate were added. The solution was cooled to 10° C., and 3.35 g of sodium percarbonate added slowly, kept stirred at the same temperature for 15 hours. After the reaction ended 250 ml of water were added and the pH of the resulting mixture adjusted to 10 with 10% acetic acid. This was kept stirred for 1 hour and the solid obtained was filtered, and subsequently washed with water and dried in a vacuum oven at 40° C. This provided 9.4 g of lansoprazol (yield: 90%).

Источник