Реакция #4816

Уравнение реакции

chloromethyl n-dodecanoate

quinuclidine

KBr

→

n-Dodecanoyloxymethylquinuclidinium Chloride

Растворители

ether

Условия реакции

Обработка

1. 1
   Другоеto react together at room temperature for 48 hrs
2. 2
   Другоеthe mixture was triturated in anydrous ether overnite
3. 3
   ДругоеThe solid was isolated by filtration under a nitrogen atmosphere
4. 4
   Промывкаthoroughly washed with anhydrous ether
5. 5
   СушкаAfter drying in vacuo over calcium sulfate at room temperature
6. 6
   Другое2.1 g (0.006 mol), 17 was obtained as a white solid, mp 170°-172°

Методика

2.49 g (0.01 mol) chloromethyl n-dodecanoate and 1.12 g (0.01 mol) quinuclidine were mixed and allowed to react together at room temperature for 48 hrs. Anhydrous ether was added to the mixture and the mixture was triturated in anydrous ether overnite. The solid was isolated by filtration under a nitrogen atmosphere and thoroughly washed with anhydrous ether. After drying in vacuo over calcium sulfate at room temperature, 2.1 g (0.006 mol), 17 was obtained as a white solid, mp 170°-172°; ir (KBr) 2960, 2930, 1765, 1470, 1120, 1090, 860 and 830 cm-1 ; pmr (CDCl3) δ 5.8 (s, 2H), 3.9 (t, 6H), 2.5 (t, 2H), 2.2 (m, 7H), 1.3 (bs, 18H) and 0.9 (t, 3H) ppm.

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