Реакция #48135
ord-dd9ff9b8188542ba8a7b2af9fd9d2e27
Уравнение реакции
(4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone
(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone
intermediate 1
(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone
4-(trifluoromethyl)phenyl boronic acid
→
title compound
(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1-(4-trifluoromethyl-phenyl)-1H-indol-2-yl]-methanone
Реактанты
(4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone
(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone
intermediate 1
(4,4-Difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone
4-(trifluoromethyl)phenyl boronic acid
Реагенты
Нет
Условия реакции
Подробные условия
See reaction.notes.procedure_details.
Обработка
- 1ДругоеIn analogy to the procedure described for the synthesis of example 6
Методика
In analogy to the procedure described for the synthesis of example 6, the title compound was synthesized from (4,4-difluoro-piperidin-1-yl)-[5-(1-isopropyl-piperidin-4-yloxy)-1H-indol-2-yl]-methanone (intermediate 1) and 4-(trifluoromethyl)phenyl boronic acid. The title compound was obtained in 52% yield as yellow foam. MS (m/e): 550.2 (MH+, 100%).