Реакция #480747

Уравнение реакции

water

2-phenylethanesulfonamide

acetic acid

trioxane

→

title compound

1,2,4,5-tetrahydro-3,2-benzothiazepine-3,3-dioxide

Растворители

methanesulfonic acid

trifluoroacetic acid

Условия реакции

Обработка

1. 1
   Экстракцияwas extracted with chloroform
2. 2
   ПромывкаThe organic layer was washed with water
3. 3
   Сушкаa saturated aqueous solution of sodium bicarbonate, dried over anhydrous sodium sulfate
4. 4
   Концентрированиеwas concentrated
5. 5
   ДругоеThe residue was purified by column chromatography on silica gel (chloroform:methanol=100:1)

Методика

To a solution of 2-phenylethanesulfonamide (3.62 g) in methanesulfonic acid (20 ml)-acetic acid (5 ml) was added a solution of trioxane (582 mg) in trifluoroacetic acid (3 ml)and the mixture was stirred for 3 hours at 35° C. To the reaction mixture was added water and was extracted with chloroform. The organic layer was washed with water and a saturated aqueous solution of sodium bicarbonate, dried over anhydrous sodium sulfate and was concentrated. The residue was purified by column chromatography on silica gel (chloroform:methanol=100:1) to give the title compound (1.78 g) having the following physical data.

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