Реакция #48027

Уравнение реакции

l-aminooxy-2-hydroxy-3-(1-piperidinyl)-propane

chloroform

heptyl isocyanate

→

N-[2-hydroxy-3-(1-piperidinyl)propoxy]-N′-heptyl-urea

Условия реакции

Обработка

1. 1
   workup.ADDITIONwas added
2. 2
   ДругоеSolvent was evaporated in vacuum
3. 3
   Другоеthe residue was purified by chromatography
4. 4
   Другоеto give pure colorless oil
5. 5
   ДругоеWhite crystalline product was obtained
6. 6
   Другоеby triturating with petroleum ether

Методика

To the solution of 1.23 g (7.1 mmol) of l-aminooxy-2-hydroxy-3-(1-piperidinyl)-propane dissolved in 20 ml of chloroform 1.0 g (7.1 mmol) of heptyl isocyanate was added and the reaction mixture was stirred for 20 hours. Solvent was evaporated in vacuum and the residue was purified by chromatography to give pure colorless oil. White crystalline product was obtained by triturating with petroleum ether.

Источник