Реакция #48001

Уравнение реакции

2-aminoindane

lithium

→

2,3,4,7-tetrahydro-1H-inden-2-ylamine

Растворители

ammonia

Условия реакции

Обработка

1. 1
   Другоеcondensed at −78° C.
2. 2
   Другоеcautiously quenched with ethanol (100 ml)
3. 3
   Температураwarmed to ambient temperature overnight
4. 4
   workup.ADDITIONWater is added
5. 5
   Экстракцияthe mixture is extracted with ether
6. 6
   Промывкаthe combined organic extracts are washed with brine
7. 7
   Сушкаdried (MgSO4)
8. 8
   Другоеevaporated

Методика

Liquid ammonia (80 ml) is condensed at −78° C. and 2-aminoindane (2 g, 15 mmol) is added, followed by lithium wire (2 g, 300 mmol) portionwise over 5 minutes. The reaction is stirred at −78° C. for 2 hours, then cautiously quenched with ethanol (100 ml) and warmed to ambient temperature overnight. Water is added, the mixture is extracted with ether and the combined organic extracts are washed with brine, dried (MgSO4) and evaporated to afford 2,3,4,7-tetrahydro-1H-inden-2-ylamine. [M+CH3CN] 177.

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