Реакция #47848

Уравнение реакции

4-chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine

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title compound

Выход 85.6%

2-(methylsulfonyl)thieno[2,3-d]pyrimidine

Выход 85.6%

Растворители

ethyl alcohol

Условия реакции

Обработка

1. 1
   Другоеwas bubbled for 5 minutes
2. 2
   workup.ADDITIONTo this solution was added 10% palladium on activated charcoal (15 g)
3. 3
   ДругоеTo the resulting mixture was bubbled hydrogen gas over night
4. 4
   ФильтрацияThe reaction mixture was filtered through Celite
5. 5
   КонцентрированиеThe filtrate was concentrated

Методика

To 500 mL round-bottom flask was added 4-chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine (15 g, 60 mmol), ethyl alcohol (300 mL), nitrogen gas was bubbled for 5 minutes. To this solution was added 10% palladium on activated charcoal (15 g). To the resulting mixture was bubbled hydrogen gas over night. The reaction mixture was filtered through Celite. The filtrate was concentrated to give the title compound (11.0 g). MS (ES+): 215 (M+H)+.

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