Реакция #47844

Уравнение реакции

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

cyclohexylamine

→

titled compound

Выход 24.0%

1-cyclohexylamino-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

Выход 24.0%

Растворители

THF

Условия реакции

Обработка

1. 1
   Другоеthe solvent was removed under a reduced pressure
2. 2
   ДругоеThe resulting residue was purified by flash chromatography

Методика

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (100 mg, 0.27 mmol) obtained in Example 18 was dissolved in THF (10 mL), and cyclohexylamine (132.86 mg, 0.15 mL, 1.34 mmol) was added dropwise thereto. The mixture was stirred for 12 hrs at RT, and the solvent was removed under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 25 mg of the titled compound (yield: 24%).

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