Реакция #47843

Уравнение реакции

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

benzylamine

sodium iodide

→

titled compound

Выход 44.0%

1-benzylamino-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

Выход 44.0%

Растворители

THF

Условия реакции

Обработка

1. 1
   Температураby refluxing for 6 hrs
2. 2
   ПромывкаThe resulting mixture washed with saturated saline
3. 3
   Экстракцияextracted with ethyl acetate
4. 4
   ДругоеThe organic layer was separated
5. 5
   Сушкаdried over anhydrous MgSO4
6. 6
   Концентрированиеconcentrated under a reduced pressure
7. 7
   ДругоеThe resulting residue was purified by flash chromatography

Методика

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (120 mg, 0.32 mmol) obtained in Example 18 was dissolved in THF (10 mL), and benzylamine (102.87 mg, 0.11 mL, 0.93 mmol) and sodium iodide (9.60 mg, 0.06 mmol) were added thereto, followed by refluxing for 6 hrs. The resulting mixture washed with saturated saline and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 56 mg of the titled compound (yield: 44%).

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