Реакция #47842

Уравнение реакции

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

morpholine

→

titled compound

Выход 83.0%

6-methoxy-1-morpholine-4-yl-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

Выход 83.0%

Растворители

THF

Условия реакции

Обработка

1. 1
   Другоеthe solvent was removed under a reduced pressure
2. 2
   ДругоеThe resulting residue was purified by flash chromatography

Методика

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (10 mg, 0.40 mmol) obtained in Example 18 was dissolved in THF (15 mL), and morpholine (175.01 mg, 0.18 mL, 2.01 mmol) was added dropwise thereto. The mixture was stirred for 12 hrs at RT, and the solvent was removed under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 126 mg of the titled compound (yield: 83%).

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