Реакция #47827

Уравнение реакции

6-Methoxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

hydroxylamine hydrochloride

pyridine

→

titled compound

Выход 80.0%

1-hydroxyimino-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

Выход 80.0%

Растворители

ethanol

Условия реакции

Обработка

1. 1
   Температураrefluxed for 1 hr
2. 2
   ПромывкаThe resulting mixture washed with saturated sodium bicarbonate
3. 3
   Экстракцияextracted with ethyl acetate
4. 4
   ДругоеThe organic layer was separated
5. 5
   Сушкаdried over anhydrous MgSO4
6. 6
   Концентрированиеconcentrated under a reduced pressure
7. 7
   ДругоеThe resulting residue was purified by flash chromatography

Методика

6-Methoxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (1.6 g, 5.19 mmol) obtained in Example 1 was dissolved in ethanol (100 mL), hydroxylamine hydrochloride (1.08 g, 15.57 mmol) and pyridine (1.64 g, 1.68 mL, 20.76 mmol) were added thereto, refluxed for 1 hr, and cooled to RT. The resulting mixture washed with saturated sodium bicarbonate and extracted with ethyl acetate. The organic layer was separated, dried over anhydrous MgSO4 and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 1.34 g of the titled compound (yield: 80%).

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