Реакция #47826

Уравнение реакции

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester

ethanol

→

titled compound

Выход 52.0%

1-ethoxy-6-methoxy-3-phenyl-1H-indene-2-carboxylic Acid Ethyl Ester

Выход 52.0%

Условия реакции

Обработка

1. 1
   Фильтрацияfiltered
2. 2
   ДругоеThe organic layer was separated
3. 3
   Концентрированиеconcentrated under a reduced pressure
4. 4
   ДругоеThe resulting residue was purified by flash chromatography

Методика

1-Bromo-6-methoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (30 mg, 0.09 mmol) obtained in Example 18 was dissolved in ethanol (3 mL), silver nitrate (15.50 mg, 0.09 mmol) was added thereto, stirred for 3.5 hrs at RT, and filtered. The organic layer was separated, and concentrated under a reduced pressure. The resulting residue was purified by flash chromatography to obtain 16 mg of the titled compound (yield: 52%).

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